Votrient 400mg Tablets | Pazopanib 400mg
Apple pharmaceuticals
Votrient 400mg Tablet (Pazopanib 400mg)
Votrient 400mg is a type of protein kinase inhibitors, the main ingredient which is used as pazopanib . It is also indicated for the treatment of advanced kidney cancer and soft tissue sarcoma Votrient 400mg is an antineoplastics medications which interfere with the development and spreadness of cancer cells in the body.
USAGE
VOTRIENT 400MG is used as a single agent to treat the renel cell carcinoma and its advanced stage It works by preventing the activity of proteins which are interferes with the growth and spread of cancer cells.Votrient 400mg is also used as a single regimen to treat the Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs
PHARMACOLOGY
Votrient 400mg belongs to an inhibitor of potent protein kinase and selective multiple receptor tyrosine kinases (RTKs) which are described in beginning of signal transduction pathways that ready for proliferation of tumor cells and affect growth critical to cell continuity and tumor progression. RTKs comes in the blockage and involves the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.
DOSAGE AND ADMINISTARTION
Votrient dosage for renal cell carcinoma and soft tissue sarcoma (cancer in joints, muscle) will be initially 800mg , the dose adjustment in 200mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day. Moderate total bilirubin >1.5 to 3 times, Votrient dose of 200mg once daily. Votrient should be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Food interaction :Avoid grapefruit juice or grapefruit juice.
PHARMACOKINETICS
Absorption:
GI tract partially absorbed, votrient with food has greater absorption Bioavailability is 14-39%. Duration of peak plasma concentration: 2-4 hr.
Distribution:
The drug Votrient 400mg has Human Plasma binding is >99%.
Metabolism:
Mainly in the liver the drug metabolized and by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Elimination:
Votrient 400mg primarily excreted through faeces approx 82%, 67% as unchanged drug and urine (<4%)with renal elimination. Terminal Elimination half-life: Approx 31 hr.
GI tract partially absorbed, votrient with food has greater absorption Bioavailability is 14-39%. Duration of peak plasma concentration: 2-4 hr.
Distribution:
The drug Votrient 400mg has Human Plasma binding is >99%.
Metabolism:
Mainly in the liver the drug metabolized and by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Elimination:
Votrient 400mg primarily excreted through faeces approx 82%, 67% as unchanged drug and urine (<4%)with renal elimination. Terminal Elimination half-life: Approx 31 hr.
PRECAUTION
Consult the doctor before to the treatment of Votrient 400mg tablets about:
Allgeric to pazopanib or any other drug products of pazopanib, which include in prescription, over the counters,vitamins,herbal remedies. Do not take immunization or vaccination without doctors advice. Inform your doctor about pregnancy and planning to pregnant. Do not breast feed while treatment with Votrient
Allgeric to pazopanib or any other drug products of pazopanib, which include in prescription, over the counters,vitamins,herbal remedies. Do not take immunization or vaccination without doctors advice. Inform your doctor about pregnancy and planning to pregnant. Do not breast feed while treatment with Votrient
MISSED DOSE
The drug dose is missed, and then takes the drug dose as soon as possible. If time to next dose reaches then leave the missed dose and follow the routine schedule. Do not have2 dose at one time. Please consult your doctor for further clarification.
DRUG INTERACTION
Strong CYP3A4 enzyme inhibitors (e.g. ketoconazole, itraconazole, voriconazole,etc) + Votrient 400mg → Increase plasma concentration.
Votrient + simvastatin → increases incidence of ALT elevation.
Votrient 400mg + PPI e.g. esomeprazole → decreases bioavailability.
Concurrent use of strong of BCRP inhibitors or P-gp (e.g. lapatinib) and inducers + Votrient 400mg →alter the exposure and distribution of pazopanib.
Votrient 400mg + rifampin(strong CYP3A4 Enzyme inducers) →decreases the plasma concentration.
Votrient + simvastatin → increases incidence of ALT elevation.
Votrient 400mg + PPI e.g. esomeprazole → decreases bioavailability.
Concurrent use of strong of BCRP inhibitors or P-gp (e.g. lapatinib) and inducers + Votrient 400mg →alter the exposure and distribution of pazopanib.
Votrient 400mg + rifampin(strong CYP3A4 Enzyme inducers) →decreases the plasma concentration.
SIDE EFFECTS
Votrient 400mg has certain side effects, If any of the symptoms occrs or not cured then call the doctor immediately Major side effects: Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnormalities; increased in bilirubin levels. Common Side effects: Nausea; loss of appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.
LACTATION
Votrient 400mg usage is not usually given during in pregnant women and the some doctors advice to either discontinue breastfeeding or the drug, in order to give importance of drug to the mother. The drug elimination into human milk and effects in the newborn baby is unknown.
OVERDOSAGE
there is no specific antidote for Votrient overdose, the drug doses upto 2000 mg can be administrated and It is check out in clinical trials and overdose treatment with votrient should consist of supportive measures.
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